Jeevika names her daughter Mansi while Manvi names her daughter Jahnvi. Viren helps Vidhi get away from her abusive husband, Harshad, and Vidhi leaves her child with them. Meanwhile, Manvi is also pregnant and reunite with the family. Jeevika finds out she is infertile due to having donated her bone marrow to Manvi while she was pregnant the first time, and they opt for surrogacy with the help of a woman Vidhi. The sisters' estranged father Mahesh also makes an appearance, and Manvi forgives him and helps him reconcile with the family. Virat later moves out to prove himself as a successful singer, and Manvi follows him. The sisters save the Chaudharys' ancestral property from being taken away by Dabbu's greedy wife and their neighbour Sweety. Virat and Jeevika are falsely imprisoned, but Manvi and Viren manage to prove them innocent.
The family later faces more obstacles due to Viren's professional rival Jaiswal sending an imposter to their house. Jeevika aborts her child and secretly donates her bone marrow to Manvi with the support of Viren. Later Jeevika lies to the family that they found another donor whose bone marrow matched with Manvi’s to get the treatment done. Manvi goes to court to stop Jeevika with Inder fighting from Manvi’s side and Viren fighting Jeevika’s. Manvi refuses of getting Jeevika’s bone marrow because she does not want her to abort her child. After all, Manvi is Jeevika’s first child. Jeevika and Viren decide it would be right to abort their child to save Manvi’s life. Jeevika’s bone marrow matches with Manvi, but she is unable to donate because she is pregnant. For her treatment to be successful, she needs a bone marrow donor. On the day of the engagement, Manvi learns that her Mumbai treatment was unsuccessful, and she has two years to live. Manvi successfully recovers, and in the process, Virat and Manvi grow closer and are engaged. Jeevika takes Manvi to Mumbai to further pursue treatment.
Troubled, Manvi reaches Chandigarh, and the family, and later Jeevika, get to know about her condition. Virat supported Manvi and decided to take her to Chandigarh. Unaware of her condition, Viren forbids Manvi to meet Jeevika and reaches Chandigarh with an unconscious Jeevika. She is forced to reveal to Virat why she cannot donate her blood to her sister. Virat takes her away from the hospital and confronts her, and breaks their friendship. Viren asks Manvi to donate her blood, but she refuses to leave Viren and Virat both angered and confused about why she is declining. She later suffers cancer Jeevika faces an accident. Virat and Manvi also fall in love with each other. Viren falls for and soon marries Jeevika. The Vadheras' sons, Viren and Virat meet Jeevika and Manvi. Manan but sides with Chandrika despite of her feelings. Chandrika, their grandmother receives marriage proposal for Jeevika from Vadheras in Chandigarh. Carefree, rebellious and younger, Manvi has just passed college.
Sweet, elder and righteous, Jeevika is a teacher in a neighbouring school. Two sisters, Jeevika and Manvi live in Rishikesh with their family.